Exosomes — ExoCoBio ASCE+, Exomage, BENEV for face and hair

Exosomes: ExoCoBio ASCE+ HRLV · BENEV PRP: platelet-rich plasma After trichoscopy Combined

Exosomes vs PRP for hair — what to choose in Baku

PRP — your plasma with platelet growth factors. Exosomes — standardized nanovesicles from stem cells. PRP is cheaper, exosomes are stronger in effect. In practice, they are often combined rather than opposed.

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Brief comparison

Paramed

PRP (platelet-rich plasma) — injections of your own plasma with a platelet concentration 3–5 times higher than normal. Platelets release growth factors (PDGF, IGF-1, EGF, VEGF) that activate hair follicles. Exosomes are standardized nanovesicles 30–150 nm, derived from adipose stem cells (ASCE+ HRLV) or umbilical stem cells (BENEV). They carry growth factors (VEGF, IGF-1, KGF, HGF), cytokines, and microRNA that activate Wnt/β-catenin signaling pathways — those that transition the follicle from a resting phase to a growth phase. The main difference: PRP is an autologous product, its effect depends on the quality of your blood; exosomes are standardized in composition and dosage. PRP is 4–5 times cheaper, but exosomes provide a more pronounced and predictable effect. They are often combined. Contraindications apply.

When to choose what

Paramed

PRP is the first-line choice for early alopecia and diffuse hair loss when an affordable course of 4–6 sessions is needed. It is also good for preparing for hair transplantation. Exosomes are the choice for pronounced androgenetic alopecia when maximum effect on dormant follicles is needed; for prolonged hair loss after acute stress; when blood draw is refused. In practice, they are often combined: a course of PRP (4 sessions) + 2 sessions of exosomes for enhancement, or exosomes as a base + supporting PRP. The complete program is selected after trichoscopy.

Autologous plasma vs standardized nanovesicles

Paramed

PRP is obtained by centrifuging 10–20 ml of your venous blood. The concentration of platelets in the resulting plasma is 3–5 times higher than normal, and growth factors are released directly from the platelets after activation. The composition and concentration depend on your blood parameters. Exosomes are extracellular vesicles isolated in the laboratory from stem cells. ExoCoBio ASCE+ HRLV — a Korean flagship, 10 billion exosomes + biotin + 1008 growth factors in one vial. BENEV — exosomes from umbilical stem cells. They activate Wnt/β-catenin signaling pathways, transitioning the follicle into the active anagen phase, and suppress DKK-1 — a protein that causes hair miniaturization in androgenetic alopecia.

PRP: your plasma, centrifugation for 15 minutes
Exosomes: laboratory product, ready vial
PRP: composition depends on blood quality
Exosomes: standardized — each batch is the same
Exosomes: activate Wnt/β-catenin and suppress DKK-1
PRP: platelet growth factors, no microRNA

FAQ

Paramed

? Which is more effective — exosomes or PRP? ⌄

Exosomes are usually stronger at the signaling level: they activate Wnt/β-catenin and suppress DKK-1, which causes hair miniaturization. PRP provides a 'concentrated cocktail' of platelet growth factors. According to modern studies, exosomes show a more pronounced increase in density, especially in androgenetic alopecia. But they are also significantly more expensive.

? Can they be combined in one course? ⌄

Yes, this is a common practice. Usually 4 sessions of PRP + 2 sessions of exosomes, or exosomes as a 'base' + supporting PRP once a month.

? What to choose for severe hair loss? ⌄

In cases of pronounced androgenetic or diffuse alopecia, exosomes provide a more pronounced effect due to their influence on Wnt/β-catenin. However, in severe AGA, neither of them can replace medication therapy.

? Is it painful? ⌄

Both options are tolerated comfortably — the scalp is less sensitive. Cooling is used, and if necessary, a local anesthetic. PRP may be less comfortable due to the blood draw stage.

? When is the result visible? ⌄

Reduction in hair loss — for both after 1–2 sessions. Visible thickening and growth of new hair — within 2–3 months after the end of the course.

Booking

Paramed

Ready to start?

Schedule a trichoscopy at Paramed — we will assess the condition of your hair and select a program with PRP, exosomes, or their combination.

Exosomes and PRP — pros and cons

Paramed

PRP (platelet-rich plasma)

Pros

Autologous — low allergy risk
Affordable price — 60–80 AZN per session
Good clinical experience in trichology
Suitable for early alopecia
Can be done more frequently without high costs

Cons

Effectiveness depends on blood quality
Requires blood draw
Composition is not standardized
Weaker influence on follicle signaling pathways
Lower chances of 'waking up' dormant follicles in advanced alopecia

Exosomes for hair (ExoCoBio ASCE+ HRLV, BENEV)

Pros

Standardized dosage — each session is the same
Strong influence on Wnt/β-catenin and DKK-1
Awaken dormant follicles — effect on density
No blood draw required
Work well for androgenetic and diffuse alopecia

Cons

4–5 times more expensive than PRP — 250–450 AZN per session
Fewer clinical studies in trichology (method is newer)
In cases of severe androgenetic alopecia — medications are needed

Exosomes — ExoCoBio, BENEV, Zishel, Promoitalia

Paramed

AZN Exosomes — ExoCoBio, BENEV, Zishel, Promoitalia

Service

Price

Dives AXC1000 (exosomes — hair or face)

Exosomal modulator: exosomes + hyaluronic acid + polynucleotides. Mesotherapy/microneedling.

200–260 AZN

ExoCoBio ASCE+ SRLV (face)

Premium flagship. Used at Oracle, Wonjin, Banobagi after laser resurfacing and microneedling.

480–550 AZN

ExoCoBio Exomage (face, sensitive skin / rosacea)

Anti-inflammatory profile; for rosacea, couperose and reactive skin.

500–580 AZN

BENEV Exosomes (face)

Premium; exosomes from umbilical stem cells. Standard partner for microneedling and RF.

450–520 AZN

Exosomes for face — standard kit

Affordable option for basic protocols and maintenance courses.

350–400 AZN

V-Tech System (Promoitalia) — face, neck, hands

Italy, Promoitalia. Synthetic exosomal structures + high-molecular-weight PDRN (20 mg/ml) + biomimetic peptides; the kit includes a mask with hyaluronic acid and plant stem cells. Applied via microneedling: face, neck, hands, feet. Protocol — 4 sessions at 14-day intervals.

$$$

ExoCoBio ASCE for hair

Premium kit: 10 billion exosomes + biotin + 1008 growth factors. Korean flagship.

380–450 AZN

BENEV Exosomes for hair

Premium kit; exosomes from umbilical stem cells. Pairs well with microneedling and RF.

350–420 AZN

Exosomes for hair — standard kit

Affordable option for maintenance courses; alternative certified kits.

250–300 AZN

Zishel Xomage H (Korea) — hair and scalp

Korea, Zishel Medical. 10 billion particles per vial: adipose-derived mesenchymal stem cell exosomes + 4 types of plant vesicles, 5 growth factors, 6 peptides, biotin and sodium hyaluronate. For hair loss and thinning; delivered by mesotherapy or microneedling. The XOMAGE line carries QR lot traceability.

$$$

ExoSignal™ Hair (Promoitalia) — hair

Italy, Promoitalia. 5 ml ampoule: synthetic exosomal structure + high-molecular-weight PDRN, 8 biomimetic peptides for the scalp, plant stem cells, vitamins, panthenol, glutathione, biotin and hyaluronic acid. 1.5–2 ml per session via microneedling; a course of at least 4 sessions at 10-day intervals, then maintenance every 2 months.

$$$

M-Exosomes Soft (Medisepte) — face, neck, décolleté, hands

Medisepte. 10 ml vial: buffalo-milk exosomes — over 0.5 billion nanoparticles per 1 ml — with sodium hyaluronate 1400–1600 kDa at 6 mg/ml. The soft, large-volume version of the M-Exosomes line for bigger areas: face, neck, décolleté, hands. A course of 4–6 sessions at 10–14 day intervals.

$$$

Purasomes SGC100+ (Skin Glow Complex) — face

Italy, Dermoaroma. AMPLEX+ technology: 20 billion bovine-colostrum exosomes and 20 growth factors plus antioxidants, peptides and plant stem cells. Radiance, even tone, recovery after inflammation. Applied through microneedling, alone or alongside another procedure.

$$$

Purasomes NC150+ (Skin Nutri Complex) — face

Italy, Dermoaroma. 20 billion colostrum exosomes and 20 biomimetic growth factors, PDRN, hyaluronic acid in two molecular weights, vitamins and amino acids. Density, firmness and structure — work on fibroblasts and collagen synthesis.

$$$

Purasomes HSC50+ (Hair & Scalp Complex) — hair

Italy, Dermoaroma. 20 billion colostrum exosomes, 200 mg across 20 growth factors, 25 mg high-molecular-weight HA (1100–1400 kDa) and 25 mg low-molecular-weight HA (80–100 kDa), 7 peptides and 8 vitamins. Resynchronises hair growth and works on the hair bulb; applied through scalp microneedling.

$$$

Exosome PDRN (MS Mesopharma) — topical

MS Mesopharma. Exosomes paired with PDRN, in 10 ml and 1500 IU vials. Topical use — this product is not injected: it is applied after microneedling, laser or a peel for recovery, hydration and a more even tone.

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