Polynucleotides (PDRN / PRDN) for hair — PhilArt SCALP, Plinest

PDRN: PhilArt SCALP · Plinest PRP: plasma lifting After trichoscopy Combined

PDRN vs PRP for hair — what to choose in Baku

PRP — your own plasma with platelets and growth factors. PDRN — standardized fragments of salmon DNA. Different molecules, different mechanisms, and in trichology, they are more often combined than compared.

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A brief comparison

Paramed

PRP (Platelet-Rich Plasma, plasma lifting) is the injection of your own plasma enriched with platelets and growth factors. Blood is drawn from a vein and centrifuged to isolate plasma with a high concentration of platelets. PDRN (polynucleotides) are injections of standardized fragments of trout/salmon DNA. PRP is an autologous product, and its composition depends on the quality of your blood. PDRN is a factory-produced product with a fixed dosage. In trichology, both are used for androgenetic alopecia, diffuse hair loss, and to increase density, but through different mechanisms. PRP has a stronger concentration of platelet growth factors (PDGF, EGF, IGF-1). PDRN has a stronger anti-inflammatory and vascular effect through A2A receptors. They are often used together in one course. There are contraindications.

When to choose what

Paramed

PRP is the first-line choice for early androgenetic alopecia, diffuse hair loss, and preparation for hair transplantation. It is also suitable as an affordable support course. PDRN is the choice for sensitive or inflamed scalp, for those refusing blood draws (fear of needles, poor veins), in cases of anemia, and during recovery after childbirth (after lactation is completed). In severe cases, the doctor often combines: 4 sessions of PRP + 2 sessions of PDRN, or alternates them over 3–6 months. If indicated, mesotherapy and/or exosomes are added.

Platelets vs DNA fragments

Paramed

PRP is obtained from your blood: 10–20 ml of venous blood is centrifuged to isolate plasma with a platelet concentration 3–5 times higher than normal. Platelets release growth factors (PDGF, EGF, IGF-1, VEGF) that activate follicles. The concentration and quality depend on your blood parameters — hemoglobin, platelets, overall condition. PDRN is a factory product made from ultra-purified trout/salmon DNA. Long chains of nucleotides are broken down in the skin into fragments that bind to A2A receptors on fibroblasts and endothelium. This activates collagenogenesis, angiogenesis, and suppresses inflammation (TNF-α, IL-6). The dosage of PDRN is always the same — it does not depend on your blood.

PRP: your plasma with platelets → growth factors (PDGF, IGF-1)
PDRN: factory fragments of DNA → A2A receptors on fibroblasts
PRP: autologous — composition depends on you
PDRN: standardized — composition is fixed
PRP: stronger in stimulating follicles
PDRN: stronger in anti-inflammation and microcirculation

FAQ

Paramed

? Which is more effective — PDRN or PRP? ⌄

It depends on the situation. With good hemoglobin and early alopecia, PRP provides a strong effect. With an inflamed scalp or anemia, PDRN works better. In clinical practice, they are often combined rather than choosing one.

? Can PRP and PDRN be done in one course? ⌄

Yes, this is standard practice. Usually alternating: one session of PRP, the next — PDRN, with an interval of 2–3 weeks. Or first 2 sessions of PRP, then 2 sessions of PDRN.

? Which is cheaper? ⌄

PRP — 60–80 AZN per session, significantly cheaper. PDRN — 300–400 AZN. The difference of 4–5 times reflects the difference in technology: PDRN is a factory product, PRP is made from your blood in 15 minutes.

? What is better after childbirth? ⌄

PDRN is usually better after childbirth. It does not require blood draws (which can be uncomfortable in cases of possible anemia), and is safer during overall recovery. But not during lactation — typically after it is completed.

? How long until results are visible? ⌄

Reduction in hair loss with both PRP and PDRN is usually seen after 1–2 sessions. Thickening and visible hair growth occurs 2–3 months after the course is completed.

? Do they replace minoxidil/finasteride for androgenetic alopecia? ⌄

No. Both PRP and PDRN are adjunct therapies that enhance the density and quality of existing hair. In cases of pronounced androgenetic alopecia, they are combined with medication therapy.

Booking

Paramed

Ready to start?

Schedule a trichoscopy at Paramed — a trichologist will assess the condition of your hair and select a program: PRP, PDRN, or their combination with mesotherapy and exosomes.

PDRN and PRP — pros and cons

Paramed

PRP (plasma lifting)

Pros

Autologous product — low risk of allergy
Strong concentration of growth factors (especially with good blood)
Affordable price — 60–80 AZN per session
Extensive clinical experience in trichology
Works well for early androgenetic alopecia

Cons

Effectiveness depends on the quality of your blood
Requires blood draw — not comfortable for everyone
Dosage is not standardized
May be uncomfortable with low hemoglobin
Weaker anti-inflammatory effect

PDRN for hair (PhilArt SCALP, Plinest)

Pros

Standardized dosage — each session is the same
Strong anti-inflammatory effect
Improves microcirculation around follicles
No blood draw — convenient after childbirth, in cases of anemia
Good for sensitive/inflamed scalp

Cons

More expensive than PRP — 300–400 AZN per session
Contraindicated in severe fish allergies
Less clinical experience specifically in trichology
Sometimes requires combination with PRP for maximum effect

Polynucleotides (PDRN / PRDN)

Paramed

AZN Polynucleotides (PDRN / PRDN)

Service

Price

Polynucleotides (PDRN / PRDN) — Plinest (Mastelli, Italy)

Original Italian PDRN from trout DNA. Skin booster for density and skin quality.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Newest (Mastelli)

Reinforced Plinest formula for mature skin and areas with marked atrophy.

420–480 AZN

Polynucleotides (PDRN / PRDN) — PhilArt EYE (under-eye)

Korea, Croma-Pharma. Special formula for thin under-eye skin — dark circles, wrinkles, thinning.

350–420 AZN

Polynucleotides (PDRN / PRDN) — PhilArt FACE

Standard face protocol: density, tone, post-acne, early signs of aging.

380–450 AZN

Polynucleotides (PDRN / PRDN) — Pluryal Silk

Switzerland, MD Skin Solutions. Accessible option for basic protocols and maintenance.

320–380 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Medium (Medixa, Italy)

PDRN 20 mg/ml + hyaluronic acid. Skin density and firmness, medium wrinkles and scars.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Piennedi Strong (Medixa, Italy)

PDRN 25 mg/ml + hyaluronic acid 2 mg/ml. Deep regeneration: face, neck, décolletage, hands, body.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran Healer (PharmaResearch, Korea)

Pure polynucleotides from salmon DNA (DOT™). Flagship for all-round anti-aging, density and skin quality.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran I (under-eye) (PharmaResearch, Korea)

Formula for the periorbital area: dark circles, thin skin, under-eye wrinkles.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Rejuran S (PharmaResearch, Korea)

High viscosity, for post-acne scars and deep skin damage.

420–480 AZN

Polynucleotides (PDRN / PRDN) — Rejuran HB (PharmaResearch, Korea)

Polynucleotides + non-crosslinked hyaluronic acid. Hydration with less discomfort, good for a first course.

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc 1.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, entry concentration. Biorevitalisation and skin quality.

320–380 AZN

Polynucleotides (PDRN / PRDN) — TwAc 2.0 (Yuma Medical, UK)

PDRN + hyaluronic acid, reinforced formula. Density and tone across all skin layers.

350–420 AZN

Polynucleotides (PDRN / PRDN) — TwAc 3.0 (Yuma Medical, UK)

PDRN 10 mg/ml + hyaluronic acid 20 mg/ml. Deformational aging, hands, décolletage (30+).

380–450 AZN

Polynucleotides (PDRN / PRDN) — TwAc Eyes (under-eye) (Yuma Medical, UK)

PDRN + hyaluronic acid for the under-eye area: dark circles, puffiness, fine lines.

350–420 AZN

Polynucleotides (PDRN / PRDN) — Elare Red PN (U-Skin Lab, Korea)

Korea, U-Skin Lab. Salmon-DNA polynucleotide skin booster. Density, tone and quality of facial skin.

350–420 AZN

Polynucleotides (PDRN / PRDN) for hair — PhilArt SCALP

Korea, Croma-Pharma. Specialized scalp protocol: microcirculation, hair thickening.

300–380 AZN

Polynucleotides (PDRN / PRDN) for hair — Plinest (Mastelli)

Italian PDRN, off-label scalp protocol. Often paired with mesotherapy and PRP.

320–400 AZN

Polynucleotides (PDRN) — ADN Restart 2% (Mesopharm)

Russia, Mesopharm. Sodium deoxyribonucleotide 2% (salmon-milt DNA fragments under 450 kDa) with tripeptide-1 and a pH 7.0 buffer, 4 ml vial. Repair and anti-ageing work; delivered by injection.

$$$

Polynucleotides (PDRN) — NucleoSpire DNA-RNA 2% (Mesopharm)

Russia, Mesopharm. Polynucleotides at 20 mg/ml (2%) as salmon-milt DNA-RNA complexes plus non-stabilised hyaluronic acid 0.3%, in 1.3 ml and 4 ml vials. Intensive revitalisation, pigmentation work and recovery after aggressive procedures.

$$$

Polynucleotides (PDRN) — POLY-N Strong (Italy)

Italy. A polynucleotide gel at 25 mg/ml in a 2 ml syringe — one of the highest PDRN concentrations on the market. Mobilises fibroblasts to rebuild collagen and elastin; for marked loss of density and skin quality.

$$$